Endocrine Abstracts

Prenatal and postnatal environment can regulate gene expression through multiple epigenetic mechanisms, being DNA methylation among the most relevant. Metabolic and reproductive function may be modified by this mechanism. Sons born to women with PCOS show altered markers of metabolic and reproductive function during childhood and adulthood. However, these functions have not been studied during puberty. The aim of the present study was to assess the global methylation pattern a...

Introduction: Amiodarone is a well-established antiarrhythmic drug frequently used in tachyarrhythmias. Side effects include hypothyroidism and hyperthyroidism. Extreme cases such as myxedematous and thyrotoxic crisis are very uncommon. Here we report one case of each of these presentations.Case Report no.1: A 73-year-old woman with history of atrial fibrillation under treatment with amiodarone presented to the emergency department with headache, nausea ...

Graves’ disease is the most common cause of hyperthyroidism in non-endemic areas and antithyroid drugs are the preferred first-line therapy in many centers. The aim of this retrospective investigation was to verify the association of remission with the achievement of normal TSH and free-T4 during the first 18 months of treatment and to compare it with negative anti-TSH-receptor antibodies at 18 months, a marker with known prognostic value. All patients diagnosed with Grav...

Background: Struma ovarii (SO) is the presence of thyroid tissue as a major cellular component in an ovarian tumour.Case report: A 35-year-old, Caucasian female, asymptomatic and with normal physical examination was submitted to left oophorectomy due to an ovarian mass (8.2×7.0×6.0 cm) detected in routine pelvic examination. Her mother also had history of oophorectomy for an ovarian tumour and partial thyroidectomy for benign thyroid nodule. Th...

Introduction: Regarding thyroid nodules, in case of follicular lesion of undetermined significance (FLUS), performing repeat fine-needle aspiration (FNA) is a common follow-up strategy. It has been suggested that a waiting period of at least 3 months between FNAs would increase the diagnostic yield. Our study aims to clarify the optimal time for repeat FNA in case of an initial FLUS result.Methods: We identified retrospectively all thyroid FNA FLUS resul...

Objective: To study the GLP-1 pattern of secretion after an oral glucose tolerance test (OGTT) in women in postpartum reassessment of previous gestational diabetes (GDM). To evaluate clinical and laboratory parameters that can influence GLP-1 secretion.Patients and methods: Forty-eight women with a history of GDM were assessed one year after childbirth determining clinical and analytical characteristics and OGTT with 75 g. We measured glucose, insulin an...

In clinical trials, the SGLT2 inhibitor Canagliflozin inhibits renal reabsorption of glucose, increases its excretion and reduces hyperglycaemia in patients with type 2 diabetes mellitus (T2DM). The increase in glucosuria and diuresis produced, results in a reduction in weight and blood pressure (BP). Moreover, It may cause genital and urinary tract infections. However, does Canagliflozin behave in the same way in routine clinical practice?Objective: To ...

Introduction: Both insulin resistance and oxidative stress are implicated in the pathophysiology of various diseases such as type 2 diabetes mellitus, atherosclerosis or liver disease. Furthermore, the uncoupling protein-1 (UCP1) is involved in induced thermogenesis, related to the pathogenesis of obesity and diabetes. The aim of this study was to assess the impact of aerobic exercise on the inflammatory profile in patients with chronic hepatitis C.Metho...

Introduction: Amiodarone use may be associated with secondary severe organ dysfunction. Thyrotoxicosis develops in 15% cases. Primary bilateral adrenal lymphoma is a rare malignancy. If frequently presents bilaterally and with symptoms of adrenal insufficiency. Symptomatology for both conditions is nonspecific, especially in the elderly, and a high suspicion index is necessary for appropriate diagnosis.Case report: A 78 year old female presented to the e...

Introduction: Adrenal masses are among the most frequent tumours in humans (ACT). A vast majority of these tumours are benign (ACAs). Only a small subset of adrenal masses are malignant adrenocortical carcinomas (ACCs). Tumour size, tumour weight, hormonal function and pathologic criteria are useful clinicopathological criteria that can result in accurate diagnosis of most ACCs and ACAs.Case report: 31-years-old woman, without relevant previous history. ...